Conn’s Syndrome: A Diagnostic Dilemma. Case Report
Conn’s syndrome or primary hyperaldosteronism is characterized by hypertension, hypokalemia and increased ratio of plasma aldosterone concentration (ng/dl) to plasma renin activity (ng/ml per hour). Primary aldosteronism occurs most commonly due to aldosterone producing adenoma (Conn’s syndrome) or bilateral adrenal hyperplasia. The clinical manisfestation may be varied. We report an atypical neurological presentation of primary aldosteronism due to an aldosterone-producing adenoma.
Primary aldosteronism is characterized by hypertension, hypokalemia, suppressed renin activity and increased aldosterone excretion and was first described by J. W. Conn in 19551. Primary aldosteronism used to be considered as a rare form of hypertension but it is now recognized to be the most common form of secondary hypertension with prevalence estimates of 5-13% of all patients with hypertension 2,3. Primary aldosteronism occurs most commonly due to aldosterone-producing adenoma (Conn’s syndrome) or bilateral idiopathic hyperplasia and less commonly due to primary (unilateral) adrenal hyperplasia, aldosterone-producing adrenocortical carcinoma or familial hyperaldosteronism4.